A77 1726 suppliers

A77 1726

CAS:: 163451-81-8

MF:: C12H9F3N2O2

MW:: 270.21

Use：: A-771726 is the active metabolite of leflunomide, a prodrug approved by the FDA for treatment of rheumatoid arthritis. A-771726 reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. It prevents activated lymphocytes from accumulating sufficient pyrimidines to support DNA synthesis (IC50s = 0.09, 3.5, and 12.5 μM for rat, mouse, and human, respectively). At higher doses, A-771726 inhibits tyrosine kinases responsible for early T cell and B cell signaling in the G0/G1 phase of the cell cycle. A-771726 has also been shown to inhibit the production of prostaglandin E2 in synoviocytes activated by TNF-α and IL-1α (IC50s = 7 and 3 μM, respectively) as well as inhibit MMP-1 and IL-6 production at concentrations >10 μM.[Cayman Chemical]

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You can find A77 1726 suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Hebei Duling International Trade Co. LTD

A77 1726
Remarks: Purity: 99%|Package: 1kg;13.00;USD|1kg;3.00;USD
TEL: +86-0311-87836622
CHINA Trader

￥13.00/1kg

￥3.00/1kg

career henan chemical co

A77 1726
Remarks: Purity: 98% | Package: 1KG;1USD
TEL: 0371-+86-0371-86658258
CHINA Reagent

￥1.00/1KG

BOC Sciences

Teriflunomide
Remarks: Purity: >98% | Package: 1g | CustNote: BOC Sciences also provides custom synthesis services for Teriflunomide.
UNITED STATES Trader