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ChemicalBook >> CAS DataBase List >>Topotecan

Topotecan suppliers

Topotecan

CAS:: 123948-87-8

MF:: C23H23N3O5

MW:: 421.45

SecurityInformation

Symbol(GHS) ：: GHS08

Signal word ：: Danger

Hazard statements ：: H340-H361d

Precautionary statements ：: P201-P202-P280-P308+P313-P405-P501

Hazard Codes ：: T,C,F,Xi

Risk Statements ：: 36/37/38-67-35-20-11-34-48-46-36

Safety Statements ：: 26-45-36/37/39-37/39-36-22-24/25-16-7

RIDADR ：: UN 3286 3/PG 2

WGK Germany ：: 2

RTECS ：: MW4025000

F ：: 3

HazardClass ：: 8

PackingGroup ：: II

Storage Class：: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications：: Muta. 1B
Repr. 2

Hazardous Substances Data：: 123948-87-8(Hazardous Substances Data)

Use：: Topotecan was launched in the US for the second-line treatment of ovarian cancer. It can be prepared in four steps from camptothecin and is a water soluble derivative of the natural product with decreased toxicity. Unlike its chemical relative irinotecan, topotecacan in not a prodrug and does not require bioactivation. It is an inhibitor of topoisomerase I. Specifically, it inhibits the release of topoisomerase I from DNA, where it relaxes supercoiled DNA, giving rise to single-strand breaks. When the replication fork reaches this complex, double-stand breaks can occur. This signals apoptosis and eventually gives rise to cell death. Evidence indicates hycamtin is safe for people with impaired hepatic function.

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You can find Topotecan suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Pushan Industry (Shaanxi) Co., Ltd.

Topotecan
Remarks: Purity: 99% | Package: 25KG
TEL: 029-81310890
CHINA Service provider

Henan Tianfu Chemical Co.,Ltd.

TIANFU-CHEM 123948-87-8 Topotecan
Remarks: Purity: 99% | Package: 25KG;5KG;1KG
TEL: 0371-+86-0371-55170693
CHINA Trader

career henan chemical co

Topotecan
Remarks: Purity: 98% | Package: 1KG
TEL: 0371-86658258
CHINA Reagent

CONIER CHEM AND PHARMA LIMITED

topotecan
Remarks: Purity: 0.99 | Package: 1kg
CHINA Trader

TargetMol Chemicals Inc.

Topotecan
Remarks: Purity: 95.19% | Package: 5mg;32USD|10mg;45USD|25mg;76USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
TEL: +1-781-999-5354
UNITED STATES Trader

￥32.00/5mg

￥45.00/10mg

￥76.00/25mg

Win-Win chemical CO., Limited

(2R,8S)-2-fluoro-1,2,3,5,6,7-hexahydropyrrolizine-8-carboxylic acid;hydrochloride
Remarks: Package: 1g,5g,10g
TEL: 0577-+86-0086-577-64498589
CHINA Trader

Shanghai UCHEM Inc.

Topotecan
Remarks: Purity: 0.99 | Package: 25kg;1kg
TEL: +862156762820
CHINA Trader

Dideu Industries Group Limited

Topotecan
Remarks: Purity: 99.9%|Package: 1g
TEL: +86-29-89586680
CHINA Trader

Finetech Industry Limited

Topotecan
Remarks: Purity: 98% | Package: 1g,10g,25g,100g,500g,1kg
TEL: 27-+86-27-8746-5837
CHINA Trader

Baoji Guokang Healthchem Co., Ltd.

Topotecan
Remarks: Purity: 0.99 | Package: 5KG;1KG
TEL: 0917-3909592
CHINA Trader