Ofloxacin suppliers

Ofloxacin

CAS:: 82419-36-1

MF:: C18H20FN3O4

MW:: 361.37

SecurityInformation

Symbol(GHS) ：: GHS07

Signal word ：: Warning

Hazard statements ：: H303

Precautionary statements ：: P270-P301+P312-P403-P501c

Hazard Codes ：: Xn,Xi

Risk Statements ：: 22-42/43-68-36/37/38

Safety Statements ：: 26-36/37/39-24/25-22-37/39-60

WGK Germany ：: 3

RTECS ：: UU8815550

HS Code ：: 29349990

Hazardous Substances Data：: 82419-36-1(Hazardous Substances Data)

Toxicity：: LD50 in male, female mice, male, female rats (mg/kg): 5450, 5290, 3590, 3750 orally; 208, 233, 273, 276 i.v.; >10000, >10000, 7070, 9000 s.c. (Ohno)

Use：: Ofloxacin is a fluoroquinolone antibiotic present as a racemic mixture. Levofloxacin, S-isomer of ofloxacin, shows a broad spectrum of antibacterial activity against both gram-positive and gram-negative bacteria. The antibacterial activity of levofloxacin is 8–128 times greater than that of the corresponding R-isomer. A novel esterase of type B1 carboxylesterase/lipase family from a marine isolate Y. lipolytica CL180 was used to resolve a racemic mixture of ofloxacin ester. This esterase showed an enantioselectivity toward R, S-ofloxacin ester, and levofloxacin was produced with an enantiomeric excess of 52 % (Kim et al. 2007).

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Wuhan Fortuna Chemical Co., Ltd