Ivacaftor suppliers

Ivacaftor

CAS:: 873054-44-5

MF:: C24H28N2O3

MW:: 392.49

Use：: In January 2012, the US FDA approved ivacaftor for the treatment of cystic fibrosis (CF) in patients who have the G551D mutation of the CF transmembrane regulator (CFTR) and are at least 6 years old. Ivacaftor (also known as VX-770) is a CFTR potentiator that increases the open probability of CFTR, thus increasing chloride secretion particularly in the 5% of CF patients with the G551D/F508 gating/ processing mutation. Ivacaftor was discovered by medicinal chemistry optimization of a lead scaffold identified through high-throughput screening of a 228,000 compound collection. In cultured bronchial epithelial cells from a CF patient with F508del, ivacaftor increased chloride secretion (EC50=81 nM). Preparation of ivacaftor is accomplished via a multistep synthesis oftwointermediates, 4-oxo-1,4-dihydroquinoline-3-carboxylic acid and 5-amino-di-tert-butylphenyl methyl carbonate, which are coupled using propane phosphonic acid anhydride (T3P) to afford the amide; deprotection of the phenol then provides ivacaftor.

More▼

You can find Ivacaftor suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Shijiazhuang Dingmin Pharmaceutical Sciences Co., Ltd.

Ivacaftor (VX-770)
Remarks: Purity: 99.5%+ | Package: 1kg;10kg;25kg
TEL: 0311-67591193
CHINA Trader

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Ivacaftor
Remarks: Purity: More Than 99% | Package: 1g
TEL: 010-87925929
CHINA Trader

Capot Chemical Co.,Ltd.

VX-770
Remarks: Purity: 0.98 | Package: 100KG;10KG;5KG;1KG
TEL: +86-（0）57185586718
CHINA Trader

Henan Tianfu Chemical Co.,Ltd.

ivacaftor
Remarks: Purity: 99% | Package: 25KG;5KG;1KG
TEL: 0371-+86-0371-55170693
CHINA Trader

career henan chemical co

VX-770
Remarks: Purity: 99% | Package: 1KG;7USD
TEL: 0371-86658258
CHINA Reagent

$7.00

BOC Sciences

Ivacaftor
Remarks: Purity: 98% | Package: 1 g | CustNote: Please reach out to us for more information about custom solutions.
TEL: +1-631-485-4226
UNITED STATES Trader

CONIER CHEM AND PHARMA LIMITED

vx 770
Remarks: Purity: 99% | Package: 1kg | CustNote: API25023L
CHINA Trader

TargetMol Chemicals Inc.

Ivacaftor
Remarks: Purity: 99.98% | Package: 1mg;32USD|5mg;74USD|10mg;129USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
TEL: +1-781-999-5354
UNITED STATES Trader

$32.00

$74.00

$129.00

Dideu Industries Group Limited

VX-770
Remarks: Purity: 99.00% | Package: 25kgs/Drum;200kgs/Drum | CustNote: ISO 9001：2015 REACH Approved Manufacturer
TEL: 86-
CHINA Trader

AFINE CHEMICALS LIMITED

IVACAFTOR
Remarks: Purity: 99% | Package: USP EP CP
TEL: 571-85134551
CHINA Trader