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ChemicalBook >> CAS DataBase List >>Diltiazem hydrochloride

Diltiazem hydrochloride suppliers

Diltiazem hydrochloride

CAS:: 33286-22-5

MF:: C22H27ClN2O4S

MW:: 450.98

SecurityInformation

Symbol(GHS) ：: GHS07

Signal word ：: Warning

Hazard statements ：: H302

Precautionary statements ：: P301+P312+P330

Hazard Codes ：: Xn,Xi,F

Risk Statements ：: 22-40-36/37/38-36-20/21/22-11

Safety Statements ：: 36-45-36/37-26-16

RIDADR ：: 3249

WGK Germany ：: 3

RTECS ：: DL0310000

F ：: 8-10

HazardClass ：: 6.1(b)

PackingGroup ：: III

HS Code ：: 29349990

Toxicity：: LD50 in male, female mice, male, female rats (mg/kg): 61, 58, 38, 39 i.v.; 260, 280, 520, 550 s.c.; 740, 640, 560, 610 orally (Nagao, 1972)

Use：: Diltiazem hydrochloride was developed and introduced inJapan as a cardiovascular agent to treat angina pectoris. Itwas observed to dilate peripheral arteries and arterioles. Thedrug increases myocardial oxygen supply by relieving coronaryartery spasm and reduces myocardial oxygen demandby decreasing heart rate and reducing overload. Diltiazemhydrochloride is used in patients with variant angina. Thedrug has electrophysiological properties similar to those ofverapamil and is used in clinically similar treatment conditionsas an antiarrhythmic agent, but it is less potent.

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Hebei Weibang Biotechnology Co., Ltd