Adriamycin suppliers

Properties

Melting point:：

205°C

Boiling point:：

617.77°C (rough estimate)

Density ：

1.3783 (rough estimate)

refractive index ：

1.6400 (estimate)

storage temp. ：

Keep in dark place,Sealed in dry,2-8°C

solubility ：

≥27.2 mg/mL in DMSO; insoluble in EtOH; ≥24.8 mg/mL in H2O with ultrasonic

form ：

solid

pka：

pKa 8.2 (Uncertain)

Water Solubility ：

Soluble

InChIKey：

AOJJSUZBOXZQNB-XFGIOHMQNA-N

SMILES：

OC1C2C(C3=CC=CC(OC)=C3C(=O)C=2C(O)=C2[C@H](C[C@](O)(C(=O)CO)CC=12)O[C@]1([H])O[C@@H](C)[C@@H](O)[C@@H](N)C1)=O |&1:18,20,29,32,34,36,r|

CAS DataBase Reference：

23214-92-8

IARC：

2A (Vol. 10, Sup 7) 1987

EPA Substance Registry System：

Doxorubicin (23214-92-8)

SecurityInformation

Symbol(GHS) ：

GHS07,GHS08

Signal word ：

Danger

Hazard statements ：

H302-H315-H319-H335-H350-H362

Precautionary statements ：

P260-P263-P280

HS Code ：

2941900000

Hazardous Substances Data：

23214-92-8(Hazardous Substances Data)

Toxicity：

An anthracycline cytotoxic antineoplastic that is produced by Streptomyces peucetius. The LD50 in mice is 9.4 mg/kg, i.v. It is a carcinogen that inhibits DNA and RNA synthesis by intercalating in double-stranded DNA with the amino sugar in the minor groove and the 90-OH group of the anthracycline ring hydrogen-bonded to the adjacent guanine. It also alters membrane fluidity and ion transport, and generates free radicals through a cytochrome P450-mediated reductive process. In humans, it causes alopecia, stomatitis, nausea, vomiting, diarrhea, cardiotoxicity (manifested by tachycardia), and potentially fatal congestive heart failure.