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ChemicalBook >> CAS DataBase List >>5-Fluorouracil

5-Fluorouracil suppliers

5-Fluorouracil

CAS:: 51-21-8

MF:: C4H3FN2O2

MW:: 130.08

SecurityInformation

Symbol(GHS) ：: GHS06,GHS08

Signal word ：: Danger

Hazard statements ：: H301-H351

Precautionary statements ：: P201-P202-P264-P270-P280-P301+P310

Hazard Codes ：: Xn,T,C,Xi

Risk Statements ：: 22-20/21/22-52-25

Safety Statements ：: 36-36/37-36/37/39-22-45-26

RIDADR ：: UN 2811 6.1/PG 3

WGK Germany ：: 3

RTECS ：: YR0350000

F ：: 10-23

Hazard Note ：: Irritant/Highly Toxic

TSCA ：: T

HazardClass ：: 6.1

PackingGroup ：: III

HS Code ：: 29335995

Hazardous Substances Data：: 51-21-8(Hazardous Substances Data)

Toxicity：: LD50 orally in Rabbit: 230 mg/kg

Use：: 5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratoses and bowen's disease. Further, it serves as a potent antineoplastic agent in clinical use. In addition to this, it acts as a DNA synthesis inhibitor.

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