1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid suppliers

1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid

CAS:: 1193383-09-3

MF:: C12H6ClF3N4O3

MW:: 346.65

Use：: Hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) enzymes act as central gatekeepers of posttranscriptional and transcriptional adaptation to hypoxia, oxidative stress, and excitotoxicity. Their catalytic activity is dependent on iron, 2-oxoglutarate (2-OG), and oxygen, and leads to the stabilization of a host of proteins, including the hypoxia-inducible transcription factors in response to oxygen availability. Inhibitors of PHD have been used to mimic a hypoxic response in order to study a range of oxygen-deprivation-related disorders, including anemia, ulcerative colitis, myocardial ischemia, stroke, and metabolic disorders. JNJ-42041935 is a selective, 2-OG competitive, and reversible inhibitor of PHD enzymes (pKis = 7.91, 7.29, and 7.65 for PHD1, 2, and 3, respectively). It is 100-fold selective for PHD compared to the related FIH (factor-inhibiting HIF) and a panel of various other enzymes. In an inflammation-induced anemia model in rats, 100 μM/kg/day JNJ-42041935 significantly increased the number of circulating reticulocytes and red blood cells, increased blood hemoglobin and hematocrit, and restored mean corpuscular volume and mean cell hemoglobin of red bloods cells.[Cayman Chemical]

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You can find 1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid suppliers, manufacturers, and distributors from countries such as CHINA, United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

ATK CHEMICAL COMPANY LIMITED

JNJ-42041935
Remarks: Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
TEL: 21-51877795
CHINA Reagent

TargetMol Chemicals Inc.

JNJ-42041935
Remarks: Purity: >=95% | Package: 1mg;34USD|2mg;48USD|5mg;80USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
TEL: +1-781-999-5354
UNITED STATES Trader

Career Henan Chemica Co

1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid
Remarks: Purity: 95%~99.99% | Package: 1KG;0.8USD|25KG;1.8USD
TEL: 0371-86658258
CHINA Trader

Zhejiang J&C Biological Technology Co.,Limited

JNJ-42041935
Remarks: Purity: 99% | Package: 5KG;1KG | CustNote: JNJ-42041935
TEL: 1-2135480471
CHINA Trader

TargetMol Chemicals Inc.

JNJ-42041935；HIF-PHD Inhibitor II
Remarks: Package: 1 mL * 10mM (in DMSO)；10 mg；2 mg；25 mg；5 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
TEL: +1-781-999-5354
UNITED STATES Reagent

LEAPCHEM CO., LTD.

JNJ 42041935
Remarks: Purity: 0 | Package: 1g; 5g; 25g; 1kg; 5kg; 25kg | CustNote: 0
TEL: 852-30606658
CHINA Trader

Aladdin Scientific

JNJ-42041935
Remarks: Purity: 99% | Package: $100.9/5mg;$150.9/10mg;$450.9/50mg;$720.9/100mg;Bulk package | CustNote: 99%
TEL: 552-7181
UNITED STATES Trader

Amadis Chemical Company Limited

JNJ-42041935
Remarks: Purity: 0.97 | Package: mgs,gs,kgs | CustNote: A904071
TEL: 571-89925085
CHINA Reagent

Cayman Chemical Company

JNJ-42041935
Remarks: Brand: Caymanchem | Product Number: 14316 | Purity: ≥98%
TEL: (800) 364-9897
UNITED STATES Trader

￥49.00/1 mg

￥123.00/5 mg

￥196.00/10 mg

DC Chemicals

JNJ-42041935
Remarks: Brand：dcchemicals | Product Number：DC8617 | Purity：>98%
TEL: +86-21-58447131
UNITED STATES Trader

￥500.00/100 mg

￥900.00/250 mg

￥1800.00/1 g