PROMETHAZINE

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H302：삼키면 유해함

  H317：알레르기성 피부 반응을 일으킬 수 있음

  H318：눈에 심한 손상을 일으킴

  H411：장기적 영향에 의해 수생생물에 유독함

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P264：취급 후에는 손을 철저히 씻으시오.

  P264：취급 후에는 손을 철저히 씻으시오.

  P270：이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.

  P272：작업장 밖으로 오염된 의복을 반출하지 마시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P301+P312：삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.

  P302+P352：피부에 묻으면 다량의 물로 씻으시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

  P310：즉시 의료기관(의사)의 진찰을 받으시오. 삼켰다면 즉시 의료기관(의사)의 도움을 받으시오.

  P321：(…) 처치를 하시오.

  P330：입을 씻어내시오.

  P333+P313：피부자극성 또는 홍반이 나타나면 의학적인 조치·조언를 구하시오.

  P363：다시 사용전 오염된 의류는 세척하시오.

  P501：...에 내용물 / 용기를 폐기 하시오.

PROMETHAZINE 화학적 특성, 용도, 생산

• 개요

  As a derivative of phenothiazine, promethazine is structurally and pharmacologically similar to chlorpromazine. It exhibits strong antihistamine activity as well as expressed action on the CNS. It potentiates action of sedative and analgesic drugs.

• 용도

  Promethazine is used for treating allergic illnesses such as hives, serum disease, hay fever, dermatosis, and also for rheumatism with expressed allergic components, for allergic complications caused by antibiotics and other medicinal drugs, and for enhancing action of analgesics and local anesthetics. Synonyms of this drug are allergen, phenergan, pipolphen, prothazine, and others.

• 정의

  ChEBI: A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.

• World Health Organization (WHO)

  Introduced in 1946, promethazine, a phenothiazine derivative has a variety of pharmacological properties. At present it is mainly used as an antihistamine and anti-motion-sickness drug. Promethazine is listed in the WHO Model List of Essential Drugs.

• 일반 설명

  Crystals. Melting point 60°C. Used as an antihistaminic.

• 공기와 물의 반응

  Turns blue on prolonged exposure to air and moisture.

• 반응 프로필

  PROMETHAZINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable or toxic gases may be generated in combination with strong reducing agents, such as hydrides.

• 건강위험

  SYMPTOMS: Symptoms of PROMETHAZINE include leucopenia; agranulocytosis; confusion; convulsions; stupor; and it potentiates the action of central nervous system depressants.

• 화재위험

  Flash point data for PROMETHAZINE are not available, however PROMETHAZINE is probably combustible.

• Clinical Use

  Promethazine, an early agent in the series, has many useful pharmacological affects other than being an antihistamine. It has significant antiemetic and anticholinergic properties. It also has sedative-hypnotic properties and has been used to potentiate the effects of analgesic drugs. Subsequent analogues, such as trimeprazine and methdilazine, are used as antipruritic agents in the treatment of urticaria.

• Safety Profile

  Poison by ingestion, intravenous, intramuscular, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: pupillary dilation, wakefulness, hallucinations, and distorted perceptions. An experimental teratogen. Other experimental reproductive effectsHuman mutation data reported. A severe eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx

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