Esomeprazole magnesium trihydrate

한글명:Esomeprazole magnesium trihydrate

카스 번호217087-09-7

상품명:Esomeprazole magnesium trihydrate

CBNumberCB9740619

분자식C34H38MgN6O7S2

포뮬러 무게731.14

MOL 파일217087-09-7.mol

화학적 성질

녹는점	184-189°C (dec.)
저장 조건	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
용해도	물에 약간 용해되고 메탄올에 용해되며 헵탄에는 거의 용해되지 않습니다.
InChI	InChI=1S/2C17H18N3O3S.Mg.H2O/c21-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;;/h25-8H,9H2,1-4H3;;1H2/q2*-1;+2;
InChIKey	VEVZQDGATGBLIC-UHFFFAOYSA-N
SMILES	C(C1N=CC(C)=C(OC)C=1C)S1C2[N-]C3=CC(OC)=CC=C3N=2[Mg+2]2(O=S(CC3N=CC(C)=C(OC)C=3C)C3[N-]C4=CC(OC)=CC=C4N2=3)O=1.O
CAS 데이터베이스	217087-09-7(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기	Xn
위험 카페고리 넘버	22
WGK 독일	3
HS 번호	2933399090

그림문자(GHS)

Esomeprazole magnesium trihydrate 화학적 특성, 용도, 생산

화학적 성질
Off-White Powder
용도
esomeprazole magnesium trihydrate for the healing of peptic ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy.
1. Zollinger-Ellison syndrome
2. Peptic ulcer, site unspecified
3. Duodenal ulcer
4. Gastric ulcer
5. Gastro-oesophageal reflux disease
Esomeprazole belongs to the family of medications known as proton pump inhibitors (PPIs). Esomeprazole is registered by the Therapeutic Goods Administration (TGA) for the following indications:
1. Gastro-Oesophageal Reflux Disease (GORD):
2. treatment of erosive reflux oesophagitis;
3. long-term management of patients with healed oesophagitis to prevent relapse;
4. symptomatic treatment of gastro-oesophageal reflux disease (GORD).
In combination with appropriate antibiotics for:
1. healing of duodenal ulcer associated with Helicobacter pylori;
2. eradication of Helicobacter pylori in patients with active or healed peptic ulcer.
3. Short-term treatment of upper gastrointestinal symptoms associated with non-steroidal anti-inflammatory drug (NSAID) (non-selective and COX-2 selective) therapy.
4. Healing of gastric ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy.
5. Prevention of gastric and duodenal ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy in patients at risk.
상표명
Nexium (AstraZeneca).
생물학적 활성
Esomeprazole magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a potent, orally active H+, K+-ATPase inhibitor. Esomeprazole magnesium trihydrate has the potential for upper intestinal disorders and gastroesophageal reflux disease research. Esomeprazole magnesium trihydrate acts as an exosome inhibitor by blocking the exosome release by inhibiting V-H+-ATPases.

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