소탈롤히드로클로라이드

한글명:소탈롤히드로클로라이드

카스 번호959-24-0

상품명:Sotalol hydrochloride

CBNumberCB9712098

분자식C12H21ClN2O3S

포뮬러 무게308.82

MOL 파일959-24-0.mol

동의어(한글)

소탈롤히드로클로라이드

화학적 성질

녹는점	218-220°C
저장 조건	2-8°C
용해도	H₂O: 20 mg/mL
물리적 상태	가루
색상	흰색에서 황백색까지
수용성	인산염 완충 식염수, DMSO, 에탄올, 물 및 메탄올에 용해됩니다.
CAS 데이터베이스	959-24-0(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기	Xi
위험 카페고리 넘버	36/37/38
안전지침서	26-36
WGK 독일	3
RTECS 번호	PB0826000
HS 번호	2935904000
독성	LD50 in male mice, rats (mg/kg): 2600, 3450 orally; 670, 680 i.p.; LD50 orally in rabbits: 1000 mg/kg; LD50 i.p. in dogs: 330 mg/kg (Lish)

그림문자(GHS)

소탈롤히드로클로라이드 화학적 특성, 용도, 생산

개요
Sotalol is a non-selective antagonist of β-adrenergic receptors (β-ARs; IC₅₀s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 μM. Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES). Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL).
화학적 성질
White Crystalline Solid
용도
Sotalol hydrochloride is used as a potent beta adrenergic antagonist, prolongs the action potential and increases the refractory period. Sotalol hydrochloride is also considered a non-selective β blocker and a potassium channel blocker with an IC50 of 43 μM.
정의
ChEBI: A hydrochloride salt that is the monohydrochloride of sotalol. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
생물학적 활성
A relatively potent pure β adrenergic antagonist, unique in possessing additional class III antiarrhythmic activity. Also available as part of the Mixed Adrenergic Tocriset™ .

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