클로로마딘온아세테이트

한글명:클로로마딘온아세테이트

카스 번호302-22-7

상품명:Chlormadinone acetate

CBNumberCB9673089

분자식C23H29ClO4

포뮬러 무게404.93

MOL 파일302-22-7.mol

동의어(한글)

클로로마딘온아세테이트

프레그나-4,6-디엔-3,20-디온,6-클로로-17-하이드록시-,아세테이트

화학적 성질

녹는점	212°C
알파	D +6° (c = 1 in CHCl3)
끓는 점	512.5±50.0 °C(Predicted)
밀도	1.1345 (estimate)
저장 조건	Sealed in dry,Store in freezer, under -20°C
용해도	클로로포름(약간 용해됨), 에틸아세테이트(약간 용해됨), 메탄올(약간 용해됨)
용해도	클로로포름(약간), 에틸아세테이트(약간), 메탄올(약간)에 용해됨
색상	황백색에서 밝은 노란색까지
최대 파장(λmax)	285nm(EtOH)(lit.)
Merck	14,2102
BRN	2633614
NIST	Chlormadinone acetate(302-22-7)
EPA	Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-chloro- (302-22-7)

위험 및 안전 성명

위험품 표기	T
위험 카페고리 넘버	60-61-40-48
안전지침서	53-22-36/37/39-45
WGK 독일	3
RTECS 번호	TU3750000
HS 번호	29372390
유해 물질 데이터	302-22-7(Hazardous Substances Data)
독성	mouse,LD50,intraperitoneal,3gm/kg (3000mg/kg),ENDOCRINE: ADRENAL CORTEX HYPOPLASIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 571, 1977.

그림문자(GHS)

클로로마딘온아세테이트 화학적 특성, 용도, 생산

개요
Chlormadinone acetate is a synthetic progestin. It binds to progesterone, androgen, and glucocorticoid receptors in vitro (K_is = 2.5, 3.8, and 16 nM, respectively, for the human receptors). Chlormadinone acetate increases the number of endometrial glands and uterine weight in β-estradiol-primed rabbits when administered at a dose of 45 μg/kg per day for five days. Chlormadinone acetate reduces testosterone-induced increases in the seminal vesicle weight of castrated male rats when administered at doses of 4.6 and 21.5 mg/kg per day for eight days.
화학적 성질
Crystalline Solid
용도
Orally active progesteron with antiandrogenic activity; has been used in combinations as an oral contraceptive. Progestogen; antineoplastic (hormonal)
World Health Organization (WHO)
Chlormadinone acetate, a synthetic progestogen, was introduced in 1965 as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, chlormadinone acetate was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by several regulatory authorities. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and chlormadinone remains available in some countries for contraceptive purposes. In some instances it is indicated for treatment of progesterone deficiency and endometriosis, and of irregular uterine bleeding due to fibroids. (Reference: (WHODI) WHO Drug Information, 84.1, 5, 1984)
Safety Profile
Suspected carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by intraperitoneal route. Human maternal and reproductive effects by ingestion, intramuscular, and possibly other routes: ovary, uterus, cervix, vagina, and fallopian tube changes; menstrual cycle changes or disorders; changes in ferthty; and other unspecified female effects. A human teratogen that causes developmental abnormalities of the endocrine system in the fetus. Experimental teratogenic and reproductive effects. An oral contraceptive. When heated to decomposition it emits toxic fumes of Cl-.

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