Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem

Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem 화학적 특성, 용도, 생산

• 일반 설명

  A cell-permeable symmetrical indolylmethanone kinase inhibitor that is more selective toward Flt3 over PDGFR either in cell-based receptor autophosphorylation (IC₅₀ = 40 nM vs. 300 nM) or in cell-free kinase reactions (IC₅₀ = 33 nM vs. 171 nM) and potently induces apoptosis in Flt3-expressing primary AML patient blasts. Affects Abl- or Kit-dependent cell growth only at much higher concentrations (IC₅₀ = 4.2 and ≥0.5 μM, respectively), while exhibiting little effect against IL-3-mediated cellular signaling. The molecular mechanism of inhibition is presumably due to interaction at the enzyme′s ATP-binding site.

• Biochem/physiol Actions

  Cell permeable: yes

Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem 공급 업체

Global(2)Suppliers