3-METHYLADENINE

한글명:3-METHYLADENINE

카스 번호5142-23-4

상품명:3-METHYLADENINE

CBNumberCB9307216

분자식C6H7N5

포뮬러 무게149.15

MOL 파일5142-23-4.mol

화학적 성질

녹는점	~300 °C (dec.)(lit.)
끓는 점	240℃
밀도	1.60
굴절률	1.8070 (estimate)
인화점	99℃
저장 조건	Keep in dark place,Sealed in dry,Room Temperature
용해도	DMSO(최대 3mg/ml) 또는 DMF(최대 10mg/ml)에 용해됩니다.
산도 계수 (pKa)	6.77±0.20(Predicted)
물리적 상태	가루
색상	하얀색
BRN	146087
안정성	제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 DMF의 용액은 -20°에서 최대 3개월 동안 보관할 수 있습니다.

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

안전지침서

24/25

WGK 독일

RTECS 번호

AU6520000

HS 번호

29335990

NFPA 704:

	0
2		0

그림문자(GHS)

3-METHYLADENINE 화학적 특성, 용도, 생산

개요
Autophagy is a multi-step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms. mTOR, whose activation is controlled by phosphoinositide 3-kinase (PI3K), is a key regulator of autophagy. 3-Methyladenine (3-MA) is a specific inhibitor of PI3K activity and one of the most widely used inhibitors of the initial phase of the autophagic process: the sequestering of cytoplasmic material by the lysosome. At 5 mM, 3-MA inhibits protein degradation in rat hepatocytes by 65%. 3-MA has been shown to block class I, class II, and class III PI3Ks, including some downstream targets, and to suppress the invasion of highly metastatic human fibrosarcoma HT1080 cells at 10 mM.
화학적 성질
White powder
용도
3-Methyladenine (3-MA) inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.
정의
ChEBI: A methyladenine that is adenine substituted with a methyl group at position N-3.
일반 설명
A widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC₅₀ = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)

3-METHYLADENINE 준비 용품 및 원자재

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