ERGOTAMINE TARTRATE

한글명:ERGOTAMINE TARTRATE

카스 번호379-79-3

상품명:ERGOTAMINE TARTRATE

CBNumberCB9279489

분자식C70H76N10O16

포뮬러 무게1313.41

MOL 파일379-79-3.mol

화학적 성질

녹는점	~195 °C (dec.)(lit.)
알파	D25 -125 to -155° (c = 0.4 in chloroform)
저장 조건	2-8°C
Merck	13,3696
BRN	6173437
CAS 데이터베이스	379-79-3(CAS DataBase Reference)
EPA	Ergotamine tartrate (379-79-3)

위험 및 안전 성명

위험품 표기	T
위험 카페고리 넘버	23/24/25-62-63
안전지침서	36/37-45
유엔번호(UN No.)	UN 1544 6.1/PG 1
WGK 독일	3
RTECS 번호	KE8225000
F 고인화성물질	3-8-10
위험 등급	6.1(b)
포장분류	III
HS 번호	29396200

그림문자(GHS)

ERGOTAMINE TARTRATE 화학적 특성, 용도, 생산

개요
Ergotamine and ergometrine belong to two kinds of ergot alkaloids. Ergot (Claviceps purpurea, 麦角) is the sclerotium of ergot fungus that grows in the rye and related cereal and forage plants. The ergot is grown in the northeast and north China and Xinjiang, Jiangsu, Zhejiang, Sichuan, and other places. At present, the method of growth of ergot is inoculation cultivation.
Traditional Chinese medicine believes that ergot is tasteless, tepid, toxic, liver meridian, and kidney meridian. The traditional usage of ergot is oral administration of extractum, 2–4 ml each time, daily amount of 6–8 ml. Its dosage forms also contain infusion, pills, injection, etc. Pharmacology of Chinese Medicine records ergot can be used for uterine contraction, uterine bleeding, and postpartum hemorrhage after delivery, incomplete recovery of uterus, retrogression, etc. The Plateau Chinese herbal medicine treatment manual records that ergot can cure migraine.
화학적 성질
Ergotamine tartrate is a crystalline solid.
물리적 성질
Appearance: White or slightly yellow fine crystalline powder with slight hygroscopicity. Solubility: Slightly soluble in water and ethanol, insoluble in ether and chloroform.
용도
Antimigraine.
Indications
Ergometrine maleate is used in the form of extract tumor injection. As a uterotonic, ergometrine maleate is mainly used for the prevention and treatment of uterine bleeding caused by weak or poor uterine contraction after delivery or abortion, as well as the incomplete recovery of postpartum uterus to accelerate the recovery of uterus.
Ergotamine tartrate is used for the treatment of migraine in the form of tablet and parenteral solution. It also can be used for other neurogenic headache as well.
일반 설명
Powder or liquid forms available as drugs. Used in obstetrics and in the treatment of migraine headaches.
공기와 물의 반응
Insoluble in water.
반응 프로필
ERGOTAMINE TARTRATE is sensitive to prolonged exposure to heat and light. . When heated to decomposition, ERGOTAMINE TARTRATE emits toxic fumes of nitrogen oxides. Protect from light and heat [EPA, 1998].
건강위험
High oral toxicity and a convulsant in humans.People with liver damage are at a greater risk.
화재위험
When heated to decomposition, ERGOTAMINE TARTRATE emits toxic fumes of nitrogen oxides. Protect from light and heat
Clinical Use
Ergonovine maleate is mainly used for the prevention and treatment of the weak uterine contraction or poor contraction caused by uterine bleeding after delivery or abortion. It is also used for incomplete recovery of postpartum uterus to accelerate the recovery of the uterus.
Ergotamine tartrate is mainly used for the treatment of migraine by relieving the symptoms. However, it is only suitable for short-term usage of headache attacks, normally does not prevent migraine. The combination of ergotamine tartrate and caffeine is better than single oral administration with the mild side effects. It also can be used for other neurogenic headaches.
Safety Profile
Poison by ingestion, intravenous, and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion: hallucinations, dstorted perceptions, convulsions, nausea or vomiting, blood pressure elevation. Experimental reproductive effects. Human mutation data reported. Used in production of drugs of abuse. When heated to decomposition it emits toxic fumes of NOx. See also ERGOT.
잠재적 노출
(Toxicity evaluation); Suspected reprotoxic hazard, Suspected of causing genetic defects. The major uses of the ergot alkaloids fall into two categories: applications in obstetrics and treatment of migraine headaches. May be used in the production of “street” drugs
운송 방법
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required
Purification Methods
It crystallises from MeOH. [Beilstein 25 III/IV 964.]
비 호환성
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, light, and heat

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