S-23

한글명:S-23

카스 번호1010396-29-8

상품명:S-23

CBNumberCB92743832

분자식C18H13ClF4N2O3

포뮬러 무게416.75

MOL 파일1010396-29-8.mol

화학적 성질

녹는점	119-121 °C
끓는 점	577.1±50.0 °C(Predicted)
밀도	1.48±0.1 g/cm3(Predicted)
저장 조건	-20°C Freezer
용해도	클로로포름(약간 용해됨), 메탄올(약간 용해됨)
산도 계수 (pKa)	12.04±0.29(Predicted)
물리적 상태	Solid
색상	흰색에서 황백색까지
optical activity	[α]/D 20±3°, c = 0.1 in chloroform
BRN	19161994
InChI	InChI=1S/C18H13ClF4N2O3/c1-17(27,9-28-12-4-5-14(19)15(20)7-12)16(26)25-11-3-2-10(8-24)13(6-11)18(21,22)23/h2-7,27H,9H2,1H3,(H,25,26)/t17-/m0/s1
InChIKey	SSFVOEAXHZGTRJ-KRWDZBQOSA-N
SMILES	C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)(=O)[C@](O)(C)COC1=CC=C(Cl)C(F)=C1

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

22-53

WGK 독일

NFPA 704:

	0
2		0

그림문자(GHS)

S-23 화학적 특성, 용도, 생산

개요
S-23, the orally bioavailable nonsteroidal SARM, is appreciated by jocks over the world for its one of a kind capacity to improve fit bulk and bone tissue. A more secure option in contrast to anabolic steroid, this particular androgen receptor modulator is incredibly powerful to lose obstinate fat. Considered by numerous individuals as an amazing form of S-4 (Andarine), S-23 is a standout amongst other execution upgrading medications to solidify muscle and increase a grainier stylish look.
용도
S 23 is a selective androgen receptor modulator.
benefits
Increments both skeletal and bulk
Advances durable bulk and perseverance gains
Perfect for muscle solidifying
Totally sets off catabolism in a calorie shortage
Builds bone quality and decreases fat mass
Improves drive in people
Encourages clients to hold increases long after a cycle
No swelling or liquid maintenance
Step by step instructions to Use S-23
생물학적 활성
S-23 is a selective androgen receptor modulator (SARM). It binds to the AR (Ki = 1.7 nM) and induces AR-mediated transcriptional activation in CV-1 cells expressing the human receptor when used at a concentration of 10 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats. It decreases testicular sperm concentration without reducing mounting behavior or the number of intromissions in intact rats when administered in combination with estradiol benzoate (Item No. 10006487). S-23 (3 mg/kg) also increases preference for sexually active intact males when administered to ovariectomized female rats.
Clinical Use
S-23 is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc as a potential male hormonal contraceptive. It binds to the androgen receptor more strongly than older drugs such as andarine with a Ki of 1.7 nM, and in animal studies it showed both a good ratio of anabolic to androgenic effects, and dose-dependent suppression of spermatogenesis with spontaneous recovery after cessation of treatment.
참고 문헌
[1] JONES A, CHEN J, HWANG D J, et al. Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception.[J]. Endocrinology, 2009, 150 1: 385-395. DOI:10.1210/en.2008-0674.
[2] JONES A, HWANG D J, DUKE C B, et al. Nonsteroidal Selective Androgen Receptor Modulators Enhance Female Sexual Motivation[J]. Journal of Pharmacology and Experimental Therapeutics, 2010, 334: 439-448. DOI:10.1124/jpet.110.168880.

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