Melanotan II

한글명:Melanotan II

카스 번호121062-08-6

상품명:Melanotan II

CBNumberCB9213757

분자식C50H69N15O9

포뮬러 무게1024.18

MOL 파일121062-08-6.mol

화학적 성질

밀도	1.43
RTECS 번호	OL4225000
저장 조건	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
용해도	H₂O: 5 mg/mL, 용해성
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	13.00±0.70(Predicted)
색상	하얀색
수용성	물에 0.70mg/ml까지 용해됨
InChIKey	JDKLPDJLXHXHNV-MFVUMRCOSA-N
CAS 데이터베이스	121062-08-6(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기	Xn
위험 카페고리 넘버	22
WGK 독일	3
HS 번호	3504009000

그림문자(GHS)

Melanotan II 화학적 특성, 용도, 생산

용도
Melanotan II acetate salt has been used to study its inhibitory effects on feeding and energy expenditure in rats. It is a lab-made chemical that is similar to a hormone found in people. Melanotan II has been shown to have melanogenesis (tanning) and aphrodisiac effects on humans.
Biochem/physiol Actions
Melanotan II is a MC3-R/MC4-R melanocortin agonist. It is a high affinity melanocortin receptor agonist (Ki values are 0.67, 6.6, 34 and 46 nM for MC1, MC4, MC3 and MC5 receptors respectively). Stimulates erectile activity, inhibits food intake and displays neuroprotective properties in vivo.
Clinical Use
Melanotan II has been a new treatment for rosacea discussed in the various rosacea support groups on the internet.
Melanotan I and Melanotan II are both analogs of the peptide hormone alpha-melanocyte stimulating hormone (a-MSH) that tend to induce skin tanning. Melanotan II has the additional effect of increasing libido.
Melanotan II is an α-MSH analog which underwent clinical trials for the treatment of erectile dysfunction. Preliminary double-blind, placebo-controlled studies demonstrated the efficacy of melanotan in inducing penile erection in men with erectile dysfunction, although in a very restricted population.Unfortunately, there are no experimental data on the mode of action of melanotan II, as melanotan II is the first α-MSH agonist inducing penile erection when injected peripherally.
Illustration of the proerectile effect of melanotan II (MT-II) in humans. Placebo (A) or MT-II (B, 25 ug/kg and C, 133 ug/kg) was injected subcutaneously in patients and RigiScan recording was performed from 6 h. Apparent erections developed in 8 of 10 men treated with MT-II. (Reproduced with permission from Wessells H et al. Effect of an alphamelanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. Urology 2000; 56:641–646.)
부작용
When given as a shot: Melanotan is POSSIBLY UNSAFE when given as a shot. It can causes nausea, stomachcramps, decreased appetite, flushing, tiredness, yawning, darkened skin, spontaneous erections of the penis, and other side effects. In some people, especially those with light skin, a change in the shape of moles, new moles, and skin cancer, have all occurred in people using melanotan.
참고 문헌
[1] SOPHIA HATZIIEREMIA. A liquid chromatographic/tandem mass spectroscopic method for quantification of the cyclic peptide melanotan-II. Plasma and brain tissue concentrations following administration in mice[J]. Rapid Communications in Mass Spectrometry, 2007. DOI:10.1002/rcm.3106.
[2] WEKWEJTPATRYK KirykAnna WojdaUrszula. Melanotan-II reverses memory impairment induced by a short-term HF diet.[J]. Biomedicine & Pharmacotherapy, 2023. DOI:10.1016/j.biopha.2023.115129.
[3] HJULER K F, LORENTZEN H F. Melanoma Associated with the Use of Melanotan-II[J]. Dermatology, 2013, 228: 34-36. DOI:10.1159/000356389.
[4] DORR R T, LINES R, LEVINE N, et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.[J]. Life sciences, 1996, 58 20: 1777-1784. DOI:10.1016/0024-3205(96)00160-9.

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