QUISQUALIC ACID

한글명:QUISQUALIC ACID

카스 번호52809-07-1

상품명:QUISQUALIC ACID

CBNumberCB9198500

분자식C5H7N3O5

포뮬러 무게189.13

MOL 파일52809-07-1.mol

화학적 성질

녹는점	185-187°C dec.
알파	D20 +17.0° (c = 2.0 in 6M HCl)
끓는 점	324.36°C (rough estimate)
밀도	1.6649 (rough estimate)
굴절률	1.6190 (estimate)
저장 조건	2-8°C
용해도	NH₄OH 1 M: 20 mg/mL, 투명, 무색
산도 계수 (pKa)	2.12±0.10(Predicted)
물리적 상태	가루
색상	흰색에서 황백색까지
수용성	에탄올, 물에 용해됩니다. 유기 용매에 불용성.
Merck	13,8177
BRN	1078734
안정성	안정적인. 강한 산화제와 호환되지 않습니다.

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

20/21/22

안전지침서

26-36

WGK 독일

F 고인화성물질

NFPA 704:

	0
3		0

그림문자(GHS)

QUISQUALIC ACID 화학적 특성, 용도, 생산

개요
L-Quisqualic acid is a natural analog of glutamate that acts as an agonist at AMPA-selective and metabotropic glutamate receptors (EC₅₀s = 170, 10, 40, and 29 nM at GluR-A, mGluR1, mGluR3, and mGluR5, respectively), as well as the ionotropic kainate receptor (GRIK4; K_i = 6.43 nM). L-Quisqualic acid is used to study receptor dynamics and as an excitotoxin to selectively destroy neurons in the brain or spinal cord.
화학적 성질
Off-White Solid
용도
Quisqualic acid is used to differentiate between mGluR-1 and mGluR-4. L-Quisqualic acid is an activator of GluR.
일반 설명
Quisqualate/ Quisqualic acid is obtained from the fruits and seeds of Quisqualis chinensis. It is an agonist at two subsets of excitatory amino acid receptors metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores and, ionotropic receptors that directly control membrane channels. L-quisqualic acid is an agonist of the neurotransmitter L-glutamate.
생물학적 활성
Glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. Sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect). Also available as part of the Group I mGlu Receptor Tocriset™ .
Purification Methods
It has been purified by ion-exchange chromatography on Dowex 50W (x 8, H+ form); the desired fractions are lyophilised and recrystallised from H2O/EtOH. It has IR (KBr) : 3400-2750br, 1830s, 1775s, 1745s and 1605s cm-1;maxand 1H NMR (NaOD/D2O, pH 13) : 3.55-3.57 (1H m, X of ABX, H-2), 3.72-3.85 (2H, AB of ABX, H-3), 1 3C NMR (D2O) : 50.1t, 53.4d, 154.8s, 159.7s and 171.3s. [Baldwin et al. J Chem Soc, Chem Commun 256 1985.] It is a quasiqualate receptor agonist [Joels et al. Proc Natl Acad Sci USA 86 3404 1989].

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