Florfenicol

한글명:Florfenicol

카스 번호73231-34-2

상품명:Florfenicol

CBNumberCB9195978

분자식C12H14Cl2FNO4S

포뮬러 무게358.21

MOL 파일73231-34-2.mol

화학적 성질

녹는점	153 °C
끓는 점	618℃
알파	26 +17.9° (DMF)
밀도	1.451±0.06 g/cm3(Predicted)
RTECS 번호	DB6034000
인화점	>110°(230°F)
저장 조건	Inert atmosphere,2-8°C
용해도	에탄올에는 25mM까지, DMSO에는 100mM까지 용해됩니다.
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	10.73±0.46(Predicted)
색상	흰색에서 황백색까지
Merck	14,4109
InChI	InChI=1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1
InChIKey	AYIRNRDRBQJXIF-NXEZZACHSA-N
SMILES	C(N[C@H](CF)[C@H](O)C1=CC=C(S(C)(=O)=O)C=C1)(=O)C(Cl)Cl
CAS 데이터베이스	73231-34-2(CAS DataBase Reference)
EPA	Florfenicol (73231-34-2)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

36/37/38

안전지침서

26-36

WGK 독일

HS 번호

29419090

NFPA 704:

	0
3		0

그림문자(GHS)

Florfenicol MSDS

Florfenicol 화학적 특성, 용도, 생산

개요
Florfenicol 는 불 화 합성 수의학 에서 주로 사용 하는 thiamphenicol 의 아날로그. 에 존재 하는 백색 분말 또는 결정성 분말, 무 취, 녹는점: 153 ℃, 비등 점: 760 mmHg에서 617.5 ° C.
용도
분석 결과 항균 에이전트 돼지, 닭 및 물고기 민감한 박테리아, 특히 호흡기 감염 및 창 자 감염으로 인 한 세균성 질병.
포장, 보관 및 운송
계속 컨테이너 건조 하 고 통풍이 잘되는 장소에 단단히 마감 했다.
개요
Florfenicol is a broad-spectrum fluorinated antibiotic and a derivative of thiamphenicol . It is active against human clinical isolates of enteric bacteria, including E. coli, Klebsiella, Enterobacter, Citrobacter, P. mirabilis, and Salmonella (MIC₅₀s = 6.3-12.5 μg/ml). Florfenicol is also active against clinical isolates of various bovine and porcine respiratory tract pathogens, including P. multocida, A. pleuropneumoniae, and B. bronchiseptica (MIC₅₀s = 0.25-4 μg/ml). It inhibits peptidyl transferase activity in 70S ribosomes isolated from E. coli when used at a concentration of 1 mM. Formulations containing florfenicol have been used in the treatment of infectious respiratory disease in cattle.
화학적 성질
White or off-white crystalline powder, odorless. Easily soluble in dimethylformamide, soluble in methanol, slightly soluble in glacial acetic acid, very slightly soluble in water or chloroform.
용도
Florfenicol is a fluorinated derivative of thiamphenicol. It is a protein synthesis inhibitor that inhibits bacterial protein synthesis by binding to ribosome 50S and 70S subunits. Florfenicol is used as an antibacterial.
제조 방법
Florfenicol is synthesised from thiamphenicol by replacing the 3-hydroxy group with fluorine, first synthesised at Schering in 1980. By replacing the hydroxy group, it was rationalised that chloramphenicol resistance via chloramphenicol acetyltransferase could be eliminated. Florfenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. It acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Florfenicol has been extensively studied with over 400 literature citations.
정의
ChEBI: Florfenicol is a carboxamide that is the N-dichloroacetyl derivative of (1R,2S)-2-amino-3-fluoro-1-[4-(methanesulfonyl)phenyl]propan-1-ol. A synthetic veterinary antibiotic that is used for treatment of bovine respiratory disease and foot rot; also used in aquaculture. It has a role as an antimicrobial agent. It is a sulfone, a secondary alcohol, an organofluorine compound, an organochlorine compound and a secondary carboxamide. It is functionally related to a dichloroacetic acid.

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