메드릴아민

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

메드릴아민 화학적 특성, 용도, 생산

• Originator

  Medrylamine,Shanghai Lansheng Corporation

• Manufacturing Process

  A 116 parts by weight of phenyl-p-methoxy-chloromethane (4- methoxybenzhydryl chloride) were added to 500 parts by weight of toluene and to the resulting mixture 65 parts by weight of 2-dimethylaminoethanol was added. Then the entire mixture was refluxed for two hours. The refluxed mixture was cooled and 250 parts by weight of a 10% solution of sodium hydroxide were added. This alkaline mixture was then steam distilled until the distillate was only weakly alkaline, for example a pH 7.5-8.
  The residue of this steam distillation was then mixed with 200 parts by weight of benzene and washed with water until the wash waters were practically neutral. The benzene solution was then evaporated to dryness until the resulting mixture was of constant weight (145 parts). This product was oily and was then dissolved in 3000 parts by weight of dry ether; and treated while being agitated with the theoretically equivalent amount of dry hydrochloric acid dissolved in ether. This product is an oily product, which solidified after standing overnight in an ice box. The ether solution was decanted off and the solidified residue was dissolved in 1500 parts by weight of dioxane, and then precipitated with 3000 parts by weight of ether while being continuously agitated. The resulting solid product was the hydrochloride of 2-(p-methoxy-α-phenylbenzyloxy)-N,N-dimethylethylamine 100 parts by weight of the desired product were obtained corresponding to a yield of 62% and having a melting point of 141°C.

• Therapeutic Function

  Antihistaminic

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