Dexmedetomidine

Dexmedetomidine 화학적 특성, 용도, 생산

• 개요

  Dexmedetomidine has an eight times increased affinity for the α2-receptor compared with clonidine and therefore produces less cardiovascular instability at comparable doses.

• 용도

  Dexmedetomidine is principally used as a sedative in mechanically ventilated patients in ICU. I t is particularly useful in those patients with delirium.

• Mechanism of action

  Dexmedetomidine is metabolised via hepatic glucuronidation, and clearance is reduced in patients with liver impairment. Very li??le unchanged drug reaches the urine, but 95% of degradation products are excreted this way (4% in faeces). There is a theoretical possibility of accumulation of metabolites in patients with renal failure, but toxicity has not been described because active metabolites of dexmedetomidine have not been identified at present.

• Pharmacokinetics

  Dexmedetomidine is freely soluble in water and has a pKa of 7.1. The pharmaceutical formulation is a clear, colourless preservative-free solution with a pH of 4.5–8. Protein binding of dexmedetomidine is 94%, with negligible displacement by drugs commonly used in anaesthetic and I CU practice. The elimination half-life is approximately 2h and the steady-state volume of distribution is 118 l. There are no significant differences in the pharmacokinetic profile in the elderly, but an enhanced clinical response is seen.

Dexmedetomidine 공급 업체

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