2,4-Dichloro-5-methylpyridine

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H301：삼키면 유독함

  H302：삼키면 유해함

  H315：피부에 자극을 일으킴

  H318：눈에 심한 손상을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

  P405：밀봉하여 저장하시오.

2,4-Dichloro-5-methylpyridine 화학적 특성, 용도, 생산

• 화학적 성질

  colorless liquid

• 용도

  2,4-Dichloro-5-methylpyridine is used as pharmaceutical intermediates.

• Synthesis

  A solution of phosphorus oxychloride in dichloromethane was added to a mixture of 2-chloro-5-methylpyridine 1-oxide and triethylamine in dichloromethane at 0 ℃. After stirring for 2 hours, the mixture is reacted at room temperature for 24 hours. After that, the water was added and the mixture was neutralized with a sodium hydroxide solution. The organic layer was washed with a saturated brine solution and the aqueous layer was extracted with ethyl acetate and washed with a saturated brine solution. The combined organic layers were dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford 2,4-Dichloro-5-methylpyridine. The by-product of this reaction is 2,6-dichloro-3-methyl-pyridine.
  

2,4-Dichloro-5-methylpyridine 공급 업체

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