All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .
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Toll-like receptor 4 (TLR4) is a member of the pattern recognition receptors (PRRs) family. It is expressed on the cell surface of endothelial cells, cardiac myocytes, and central nervous system (CNS). This gene located on human chromosome 9q32–33.
Biochem/physiol Actions
Toll-like receptor 4 (TLR4) serves as a receptor for lipopolysaccharide (LPS). It activates innate immune cells and stimulates inflammatory signal transduction. Mutations in the TLR4 gene is linked with endotoxin hyporesponsiveness.
