Clostebol

한글명:Clostebol

카스 번호1093-58-9

상품명:Clostebol

CBNumberCB8730750

분자식C19H27ClO2

포뮬러 무게322.87

MOL 파일1093-58-9.mol

화학적 성질

녹는점	188-190°
알파	D20 +148° (CHCl3)
끓는 점	448.4±45.0 °C(Predicted)
밀도	1.0514 (estimate)
용해도	DMF: 20 mg/mL; DMSO: 30 mg/mL; DMSO:PBS (pH 7.2) (1:10): 0.09 mg/mL; Ethanol: 20 mg/mL
물리적 상태	결정성 고체
산도 계수 (pKa)	14.99±0.70(Predicted)
CAS 데이터베이스	1093-58-9(CAS DataBase Reference)
NIST	4-Chloro-17beta-hydroxyandrost-4-en-3-one(1093-58-9)

위험 및 안전 성명

위험품 표기	Xn
위험 카페고리 넘버	40
안전지침서	36/37
DEA Controlled Substances	CSCN: 4000 CSA SCH: Schedule III NARC: No

그림문자(GHS)

Clostebol MSDS

Clostebol 화학적 특성, 용도, 생산

개요
Clostebol (Item No. 21168) is an analytical reference standard that is categorized as an androgenic anabolic steroid. Clostebol is a chlorinated form of testosterone (Item Nos. 15645 | ISO60154) that has been used as an athletic performance enhancer and to fatten cattle. It is also detectible in urine. Formulations containing clostebol have been used to treat osteoporosis, anorexia, and certain types of liver disease. Clostebol is regulated as a Schedule III compound in the United States. This product is intended for research and forensic applications.
용도
Clostebol is an anabolic steroid. This is a controlled substance.
Synthesis
Clostebol can be synthesized from 4,5-Epoxy-androstan-17β-ol-3-one by acidification with 25% hydrochloric acid.
Procedure：8.50 g epoxide (4,5-Epoxy-androstan-17β-ol-3-one) was dissolved in 150 ml Acetone and treated with 14 ml of 25% hydrochloric acid. An immediate color shift of the reaction mixture from light yellow to deep blue can be observed. After stirring for 30 h at room temperature, a complete conversion of the epoxide (4,5-Epoxy-androstan-17β-ol-3-one) can be monitored by TLC. The reaction mixture was diluted with 400 ml water, leading to the formation of a blue-black solid precipitating from the solution. After evaporation of acetone, the remaining aqueous solution was extracted several times with 200 ml dichloromethane. The combined organic extracts were washed with saturated sodium bicarbonate solution and sodium chloride solution before drying over magnesium sulfate. The crude product was chromatographed on silica gel by using hexane-ethyl acetat (1:1) and followed by a recrystallization from acetone. The isolated product Clostebol was obtained as yellowish crystals (4.50 g; 51%).

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