다이메티스테론

다이메티스테론 화학적 특성, 용도, 생산

• Originator

  Oracon,Mead Johnson,US,1965

• Manufacturing Process

  A solution of a Grignard reagent, employing 1-propyne (8 grams) was prepared. To this reagent there was added the 3,3 ethylenedioxy derivative (4 grams) of 6-α-methylandrost-4-ene-3,17-dione in tetrahydrofuran (100 ml), and the mixture heated under reflux for 3 hours. After decomposition of the complex with aqueous ammonium chloride, the product was isolated with ether and treated with 90% acetic acid (50 ml) for 30 minutes at 100°C. The product obtained by pouring the mixture into water and extracting with ether was crystallized from aqueous methanol. 17β-Hydroxy-6α-methyl-17α-(prop- 1-ynyl)androst-4-en-3-one formed plates MP 99° to 102°C.

• Therapeutic Function

  Progestin

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