ANTI-MICROPHTHALMIA TRANSCRIPTION FACTOR

ANTI-MICROPHTHALMIA TRANSCRIPTION FACTOR 화학적 특성, 용도, 생산

• 용도

  Anti-MITF antibody has been used in immunohistochemistry and chromatin immunoprecipitation.

• 일반 설명

  MITF (microphthalmia-associated transcription factor) is a basic helix-loop-helix, leucine-zipper transcription factor. It is located on human chromosome 3p13.

• Biochem/physiol Actions

  MITF is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

ANTI-MICROPHTHALMIA TRANSCRIPTION FACTOR 공급 업체

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