6-Biopterin

한글명:6-Biopterin

카스 번호22150-76-1

상품명:6-Biopterin

CBNumberCB8691190

분자식C9H11N5O3

포뮬러 무게237.22

MOL 파일22150-76-1.mol

화학적 성질

녹는점	>210°C dec.
알파	D24 -50° (c = 0.4 in 0.1N HCl); D24 -26° (c = 0.92 in 0.1N NaOH)
끓는 점	379.74°C (rough estimate)
밀도	1.3472 (rough estimate)
굴절률	1.7610 (estimate)
저장 조건	2-8°C
용해도	산 수용액(약간 용해됨, 가열, 초음파 처리)
물리적 상태	백색 내지 담황색 분말.
산도 계수 (pKa)	13.18±0.20(Predicted)
색상	흰색에서 밝은 노란색
Merck	13,1229
BRN	87860
안정성	흡습성
CAS 데이터베이스	22150-76-1(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기	Xi
위험 카페고리 넘버	36/37/38
안전지침서	26-36
WGK 독일	3
RTECS 번호	UO3506000
F 고인화성물질	10-23
HS 번호	29339900
독성	sln-par-dmg 10 mg/L MUREAV 128,147,84

그림문자(GHS)

6-Biopterin 화학적 특성, 용도, 생산

개요
6-Biopterin (L-Biopterin) is the oxidized form of tetrahydro-L-biopterin (BH4), a nitric oxide synthase (NOS) cofactor. L-Biopterin can be reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC50 = 0.2 μM after 48 hrs). L-Biopterin is rarely found under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo.
화학적 성질
Crystalline Solid
용도
L-Biopterin is a pteridine widely distributed in nature; naturally occurring as the L-erythro-form. Considered as a growth factor for some insects. Fluoresces with a blue color in alkaline solution.
정의
6-Biopterin is an enzymatic cofactor derived from pterin and involved in certain oxidation-reduction reactions. It is a biopterin in which the 1,2-dihydroxypropyl group has (1R,2S)-configuration; naturally occurring form. It is an enantiomer of a D-erythro-biopterin.
주요 응용
6-Biopterin is an oxidation product from the melanogenesis regulating cofactor (6R)5,6,7,8 tetrahydrobiopterin (6-BH4). In vitro, 6-Biopterin is cytotoxic to melanocytes. However, in vivo, 6-Biopterin is rapidly and sequentially reduced back to 6-GH4 via q-BH2. Recent studies suggest that 6-Biopterin among other pteridines may be a useful non-invasive biomarker for cancer.
제조 방법
Biopterin is synthesized by reacting 2,4,5-triamino-6-hydroxypyrimidine with 5-deoxy-L-arabinosone in aqueous solution at pH of about 7.5 to 10, acidifying and then recrystallizing by dissolving in basic solution and precipitating with acid. 5-deoxy-L-arabinosone is prepared by oxidizing S-deoxy-L-arabinose, which is prepared from L-rhamnose, using cupric acetate.
Process for the synthesis of biopterin
Safety Profile
Moderately toxic by ingestion andintraperitoneal routes. Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx.

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