InSolution Rapamycin - Calbiochem

InSolution Rapamycin - Calbiochem 화학적 특성, 용도, 생산

• 일반 설명

  Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC₅₀ = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G₁ phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G₁ phase.

• Biochem/physiol Actions

  Primary TargetMammalian target of rapamycin (mTOR)

InSolution Rapamycin - Calbiochem 공급 업체

Global(2)Suppliers