성장호르몬방출펩티드

한글명:성장호르몬방출펩티드

카스 번호87616-84-0

상품명:Growth hormone releasing peptide

CBNumberCB8421540

분자식C46H56N12O6

포뮬러 무게873.01

MOL 파일87616-84-0.mol

동의어(한글)

성장호르몬방출펩티드

화학적 성질

녹는점	>160o C (Dec.)
끓는 점	1407.0±65.0 °C(Predicted)
밀도	1.333±0.06 g/cm3(Predicted)
저장 조건	−20°C
용해도	메탄올(약간 용해됨), 물(약간 용해됨)
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	13.42±0.46(Predicted)
색상	흰색에서 황백색까지
시퀀스	is-D-Trp-Ala-Trp-D-Phe-Lys-NH2\|H-His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
InChIKey	WZHKXNSOCOQYQX-FUAFALNISA-N
SMILES	C(N)(=O)[C@H](CCCCN)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](C)NC(=O)[C@@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](CC1N=CNC=1)N
CAS 데이터베이스	87616-84-0(CAS DataBase Reference)

위험 및 안전 성명

WGK 독일

그림문자(GHS)

성장호르몬방출펩티드 화학적 특성, 용도, 생산

개요
Growth hormone-releasing peptides (GHRPs) are synthetic, non-natural peptides endowed with potent stimulatory effects on somatotrope secretion in animals and humans. They have no structural homology with GHRH and act via specific receptors present either at the pituitary or the hypothalamic level both in animals and in humans.
용도
Growth hormone releasing peptide-6 can promote the secretion of growth hormone, regulate food intake, increase weight, and promote animal growth.
Biological Functions
Growth hormone releasing peptide (GHRH) is an endocrine hormone produced in the hypothalamus that acts on the receptors (GHRH-R) of the anterior pituitary gland to stimulate the release of growth hormone (GH). GHRH includes GHRH-2 and GHRH-6, which have slightly different functions. GHRH-2 is widely used to diagnose patients with growth hormone deficiency (GHD) and is believed to induce not only growth hormone (GH) release, but also adrenocorticotropic hormone (ACTH) release. GHRH-6 is part of a group of synthetic small peptides with potent growth hormone releasing activity, which has cellular and cardioprotective effects and can be used in heart disease treatment research.
Mechanism of action
Growth hormone releasing peptide is generally accepted that GHRPs stimulate the release of GH by acting at the level of the pituitary through a receptor different to that for the endogenous GH-releasing hormone (GHRH). In addition, it has been reported that there are specific binding sites for these peptides in the hypothalamus and that systemic administration of GHRPs increases the expression of the immediate early gene c-fos in a subpopulation of hypothalamic neurons.
부작용
Carpal tunnel syndrome.Increased insulin resistance.
Type 2 diabetes.
Swelling in the arms and legs (edema)
Joint and muscle pain.
For men, enlargement of breast tissue (gynecomastia).
Increased risk of certain cancers.
Physiological effects
Growth hormone releasing peptide (GHRP) is a cyclase inhibitor that blocks the release of endogenous growth hormone.The peptide acts on both igf-i and somatotrophs, with receptor activity in the hypothalamus.GHRP can be used to increase body weight and control obesity.It has been shown to stimulate cell division and inhibit apoptosis in vitro.
Solubility in water
It is recommended to reconstitute the lyophilized growth hormone releasing peptide in sterile 18MΩ-cm H₂O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.

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