Leuprorelin

한글명:Leuprorelin

카스 번호53714-56-0

상품명:Leuprorelin

CBNumberCB8398455

분자식C59H84N16O12

포뮬러 무게1209.4

MOL 파일53714-56-0.mol

화학적 성질

알파	D25 -31.7° (c = 1 in 1% acetic acid)
밀도	1.44±0.1 g/cm3(Predicted)
저장 조건	−20°C
용해도	DMSO(약간 용해됨), 메탄올(약간 용해됨), 물(약간 용해됨)
산도 계수 (pKa)	9.82±0.15(Predicted)
수용성	1mg/ml로 물에 용해됨
안정성	흡습성
InChIKey	RGLRXNKKBLIBQS-VAZQWRJQNA-N
CAS 데이터베이스	53714-56-0(CAS DataBase Reference)

위험 및 안전 성명

안전지침서	22-24/25
WGK 독일	2
RTECS 번호	OH6390000
유해 물질 데이터	53714-56-0(Hazardous Substances Data)

그림문자(GHS)

Leuprorelin MSDS

Leuprorelin 화학적 특성, 용도, 생산

화학적 성질
Hygroscopic, white or almost white powder.
용도
Gonadotropin releasing hormone (gonadorelin) analogue; treatment of prostate cancer.
정의
ChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-leucyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. Leuprorelin is a synthetic nonapeptide analogue of gonadotropin-releasi g hormone, and is used as a subcutaneous hydrogel implant (particularly as the acetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.
Indications
Leuprolide is a potent LH-RH agonist for the first several days to a few weeks after initiation of therapy, and therefore, it initially stimulates testicular and ovarian steroidogenesis. Because of this initial stimulation of testosterone production, it is recommended that patients with prostatic cancer be treated concurrently with leuprolide and the antiandrogen flutamide (discussed earlier). Leuprolide is generally well tolerated, with hot flashes being the most common side effect.
Synthesis
The synthesis process of Leuprorelin includes the following steps:
(1) Fmoc-Pro-HMPB-AM resin is obtained from Fmoc-Pro-OH and HMPB-AM resin with a substitution degree of 0.2mmol/g～1.2mmol/g as starting materials;
(2) The Fmoc-Pro-HMPB-AM resin was coupled one by one by Fmoc/tBu solid phase method to connect amino acids with protective groups in sequence, and the side chain fully protected leuprolide precursor peptide-HMPB-AM was synthesized Resin;
(3) Cut the side chain fully protected leuprolide precursor peptide-HMPB-AM resin to obtain the side chain fully protected leuprolide precursor peptide;
(4) Fully protected side chain leuprolide precursor peptide undergoes ethylamination to obtain side chain fully protected leuprolide;
(5) Leuprolide is fully protected on the side chain by removing the side chain protecting group to obtain the crude leuprolide peptide;
(6) The crude leuprorelin peptide is separated and purified by a high-pressure liquid phase column and lyophilized to obtain the leuprolide refined peptide.

Leuprorelin 준비 용품 및 원자재

Leuprorelin 공급 업체

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