C-REACTIVE PROTEIN, HUMAN

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H290：금속을 부식시킬 수 있음

• 예방조치문구

  P234：원래의 용기에만 보관하시오.

  P390：물질손상을 방지하기 위해 누출물을 흡수시키시오.

C-REACTIVE PROTEIN, HUMAN 화학적 특성, 용도, 생산

• 용도

  For immunological applications in the preparation of antisera

• 일반 설명

  Recombinant, human C-reactive protein expressed in E. coli. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca²⁺-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer.

• Biochem/physiol Actions

  C-reactive protein (CRP) plays a key role in the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release, and the production of interleukin-6 and tumor necrosis factor-α. It participates in the uptake of low-density lipoprotein in macrophages. CRP levels are elevated in people suffering from appendicitis, cholecystitis, pancreatitis, and meningitis. It plays a vital role in the pathophysiology of cardiovascular disease. Hence it is used as a marker of infection and cardiovascular events.

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