Betahistine dihydrochloride

한글명:Betahistine dihydrochloride

카스 번호5579-84-0

상품명:Betahistine dihydrochloride

CBNumberCB8390055

분자식C8H14Cl2N2

포뮬러 무게209.12

MOL 파일5579-84-0.mol

화학적 성질

녹는점	150-154 °C
저장 조건	2-8°C
용해도	물에 매우 잘 녹고, 에탄올(96%)에 잘 녹으며, 2프로판올에는 거의 녹지 않습니다.
물리적 상태	가루
색상	옅은 노랑
안정성	흡습성
InChI	InChI=1S/C8H12N2.2ClH/c1-9-7-5-8-4-2-3-6-10-8;;/h2-4,6,9H,5,7H2,1H3;2*1H
InChIKey	XVDFMHARQUBJRE-UHFFFAOYSA-N
SMILES	C1(CCNC)=NC=CC=C1.Cl.Cl
CAS 데이터베이스	5579-84-0(CAS DataBase Reference)

위험 및 안전 성명

안전지침서

24/25

WGK 독일

RTECS 번호

UT2969000

HS 번호

29333990

NFPA 704:

	1
2		1

그림문자(GHS)

Betahistine dihydrochloride MSDS

Betahistine dihydrochloride 화학적 특성, 용도, 생산

개요
Betahistine dihydrochloride (BH.2HCl) is an orally active histamine analog which has been used to control vertigo, lack of hearing and tinnitus related to Ménière’s disease. The mechanism of BH.2HCl is to reduce the pressure of the membranous labyrinth that results in enhancement of the microvasculature circulation and improves the signs of Ménière’s disease. Peroral administration undergoes extensive first-pass metabolism and gastric irritation in patients with peptic ulcer. In treatment of vertigo, a uniform and constant supply of drug is required in order to maintain steady-state concentration of the drug in the body. Unfortunately, BH.2HCl possesses a short half-life of about 3–4 h and requires frequent administration of the drug,12–15 thereby making it an ideal candidate for controlled release preparations.
화학적 성질
white to light yellow crystalline powder
용도
Betahistine is belongs to a group of medications used to treat vertigo associated with Ménière's disease. Vertigo is a condition that causes sufferers to have a sensation of rotation or movement of themselves or their surroundings. Ménière's disease is a disorder of the inner ear that causes vertigo in addition to symptoms such as ringing in the ears, headache, and loss of hearing.
Betahistine is used to reduce the number of episodes of vertigo associated with Ménière's disease. It is believed to work by decreasing the pressure in the ear. This pressure is believed to contribute to the sense of dizziness, nausea, and ringing in the ears and hearing loss that people with Ménière's disease experience.
일반 설명
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
부작용
Stomach upset, nausea, and headache may occur. This medication may also rarely cause drowsiness. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including:
rash
itching/swelling (especially of the face/tongue/throat)
severe dizziness
trouble breathing
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

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