Protein Disulfide Isomerase from bovine liver has been used:
to study the functional role of PDI in parasite infection and the interaction between macrophage PDI and?L. chagasi
in the in vitro translation reaction for the generation of disulfide bonds
in insulin-disulfide reduction assay and peptide binding assay
as a positive control in thiol-disulfide oxidoreductase activity assay
일반 설명
Protein disulfide isomerase (PDI) from bovine liver is a homodimer with a molecular weight of 107 kDa with the monomer corresponding to 57 kDa. The isoelectric point (pI) is approximately 4.2. The enzyme is a glycoprotein with 12% total carbohydrate content comprising of mannose, galactose, N-acetyl neuraminic acid (NANA) and 2-acetamido-2-deoxyglucose. PDI is an ubiquitous redox chaperone enzyme. It belongs to the, thioredoxin superfamily and is high conserved.
Biochem/physiol Actions
Protein Disulfide Isomerase (PDI) is mainly located in the endoplasmic reticulum (ER), where it assists in protein-folding and thiol-disulfide exchanges. It aids protein refolding in vitro allowing recombinant proteins to achieve their native state.
EC 5.3.4.1 공급 업체
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