BAY-1895344 (hydrochloride)

BAY-1895344 (hydrochloride) 화학적 특성, 용도, 생산

• 개요

  BAY-1895344 is an inhibitor of ataxia-telangiectasia and Rad3-related protein (ATR) kinase that inhibits proliferation in a panel of human tumor cell lines (mean IC₅₀ = 78 nM). It halts tumor growth in ovarian and colorectal mouse xenograft models and induces complete tumor remission in mantle cell lymphoma mouse xenograft models. BAY-1895344 also exhibits synergistic anti-tumor activity with radium-223 in a mouse xenograft model of castration-resistant prostate cancer bone metastases.

BAY-1895344 (hydrochloride) 공급 업체

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