1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
한글명:1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
카스 번호28289-54-5
상품명:1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
CBNumberCB8254906
분자식C12H15N
포뮬러 무게173.25
MOL 파일28289-54-5.mol
화학적 성질
| 녹는점 | aprox. 36°C |
| 끓는 점 | 128-132 °C12 mm Hg(lit.) |
| 밀도 | 1.001±0.06 g/cm3(Predicted) |
| 저장 조건 | Inert atmosphere,Room Temperature |
| 용해도 | 클로로포름(약간 용해됨), 디클로로메탄(약간 용해됨), 아세트산에틸(약간 용해됨) |
| 물리적 상태 | 고체 |
| 물리적 상태 | 단단한 모양 |
| 산도 계수 (pKa) | 8.66±0.40(Predicted) |
| 색상 | 연한 노란색에서 밝은 노란색까지 |
| Merck | 13,6319 |
| 안정성 | 안정적인. 강한 산화제와 호환되지 않습니다. |
| 위험품 표기 | T |
| 위험 카페고리 넘버 | 25-39/23/24/25 |
| 안전지침서 | 45 |
| 유엔번호(UN No.) | UN 2811 6.1/PG 2 |
| WGK 독일 | 3 |
| RTECS 번호 | UT8358900 |
| 위험 등급 | 6.1(b) |
| 포장분류 | III |
| 유해 물질 데이터 | 28289-54-5(Hazardous Substances Data) |
| 독성 | Human toxicity originally discovered when it was an unexpected by-product from the illicit synthesis of a heroin substitute (i.e., meperidine analog). Currently used experimentally as the primary animal model for the study of Parkinson’s disease. MPTP is a neurotoxicant that is activated to 1-methyl-4-phenylpyridinium ion (MPP1) by the actions of monoamine oxidase B located in the mitochondria of brain astrocytes. The MPP1 is then transported into dopamine, and to a lesser extent, other monoaminergic neurons. Once inside these dopamine neurons in the substantia nigra, it destroys these neurons by mechanisms that may involve an oxidative cascade and/or inhibition of electron transport. Intoxication causes a parkinsonism syndrome almost identical in signs and symptoms to Parkinson’s disease, including rigidity, bradykinesia, tremor, and postural instability. In the event of known ingestion, immediate (but not delayed) administration of a monoamine oxidase inhibitor (especially one selective for MAO-B like deprenyl) and dopamine uptake inhibitor can be therapeutic. |
