CID 2745687

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

CID 2745687 화학적 특성, 용도, 생산

• 개요

  GPR35 is a G protein-coupled receptor that is activated by kynurenic acid and 2-acyl lysophosphatidic acids (e.g., 2-oleoyl lysophosphatidic acid). It is expressed predominantly on immune cells, the brain, and in the gastrointestinal tract. GPR35 is overexpressed in gastric cancer cells. CID-2745687 is a reversible, competitive antagonist of GPR35, blocking activation by the synthetic agonist pamoic acid with a K_i value of 12.8 nM. It less potently blocks activation of GPR35 by zaprinast (IC₅₀ = 160 nM). It shows ~57-fold selectivity for GPR35 over the related receptor GPR55 (IC₅₀ = 9.08 μM).

• 용도

  CID 2745687 is used as a GPR35 antagonist, with potential application towards immune or gastrointestinal system regulation.

CID 2745687 공급 업체

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