Cefotetan disodium

한글명:Cefotetan disodium

카스 번호74356-00-6

상품명:Cefotetan disodium

CBNumberCB82130367

분자식C17H18N7NaO8S4

포뮬러 무게599.6

MOL 파일74356-00-6.mol

화학적 성질

끓는 점	798℃
RTECS 번호	XI0330600
저장 조건	2-8°C
용해도	산성 수용액에 자유롭게 용해됨
물리적 상태	가루

위험 및 안전 성명

위험품 표기	Xn
위험 카페고리 넘버	20/21/22-36/37/38
안전지침서	26-36
WGK 독일	3
HS 번호	29419000
독성	LD50 in male mice, rats (g/kg): 6.35, 8.48 i.v.; 8.12, 8.37 i.p.; >10 orally and s.c. both species (Imamura)

그림문자(GHS)

Cefotetan disodium 화학적 특성, 용도, 생산

개요
Cefotetan disodium is a β-lactamase resistant, second generation cephalosporin with a serum half-life of about three hours, permitting twice-daily dosing.
용도
Cefotetan Disodium is a related compound of Cefotetan (C242970), an antibiotic related to Cephalosporin that is used to treat bacterial infections.
정의
ChEBI: The disodium salt of cefotetan.
Clinical Use
Cefotetan (Cefotan) is a third-generation cephalosporin thatis structurally similar to cefoxitin. Like cefoxitin, cefotetanis resistant to destruction by β-lactamases. It is also a competitiveinhibitor of many β-lactamases and causes transient inactivation of some of these enzymes. Cefotetan is reportedto synergize with β-lactamase–sensitive β-lactams but, unlikecefoxitin, does not appear to cause antagonism.
The antibacterial spectrum of cefotetan closely resemblesthat of cefoxitin. It is, however, generally more activeagainst S. aureus, and members of the Enterobacteriaceaefamily sensitive to both agents. It also exhibits excellentpotency against H. influenzae and N. gonorrhoeae, includingβ-lactamase–producing strains. Cefotetan is slightly lessactive than cefoxitin against B. fragilis and other anaerobes.Enterobacter spp. are generally resistant to cefotetan, andthe drug is without effect against Pseudomonas spp.Cefotetan has a relatively long half-life of about 3.5hours. It is administered on a twice-daily dosing schedule. Itis excreted largely unchanged in the urine. Aqueoussolutions for parenteral administration maintain potency for24 hours at 25°C. Refrigerated solutions are stable for 4 days.
Cefotetan contains the MTT group that has been associatedwith hypoprothrombinemia and alcohol intolerance.Another cephalosporin that lacks these properties should beselected for patients at risk for severe bleeding or alcoholism.

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