L-A-HYDROXYGLUTARIC ACID DISODIUM)

L-A-HYDROXYGLUTARIC ACID DISODIUM) 화학적 특성, 용도, 생산

• 개요

  L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels. L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.

• 화학적 성질

  White Solid

• 용도

  A potential inhibitor of glutamate carboxypeptidase.

• 일반 설명

  Glutamic acid is metabolized to α-Hydroxyglutaric acid in an NAD-dependent manner by cell-free extracts of Peptococcus aerogenes. It is formed as an intermediate during glyoxylic acid metabolism in bacteria.

L-A-HYDROXYGLUTARIC ACID DISODIUM) 공급 업체

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