Chronic dermal ulcers treatment (promotes
the proliferation of mesenchymally-derived cells).
Indications
Becaplermin (Regranex) is a recombinant human
platelet–derived growth factor (rhPDGF-BB) which is
thought to enhance wound healing by stimulating granulation
tissue. It is approved for the treatment of lower
extremity neuropathic ulcers extending to the subcutaneous
tissue in diabetic patients with an adequate blood
supply. Local irritant reactions (erythema, burning,
pain) occur in a minority of patients.
Clinical Use
Becaplermin, Regranex Gel, an endogenous polypeptidethat is released from cells that are involved in the healingprocess, is a recombinant human platelet–derived growthfactor (rhPDGF-BB). It is a growth factor that activates cell proliferation,differentiation, and function, and it is released from cells involvedin the healing process.Becaplermin is formulated as a gel recommended fortopical use in the treatment of ulcerations of the skin secondaryto diabetes.
