포사빈나트륨

포사빈나트륨 화학적 특성, 용도, 생산

• 개요

  Cytarabine ocfosfate is the first orally active stearate derivative of cytarabine introduced for the treatment of certain types of malignancies including myelodysplastic syndromes that eventually evolve into acute leukemia. Cytarabine is one of the most effective drugs for treating acute myeloid leukemia but suffers from poor bioavailability. As a monophosphorylated analog of cytarabine, the title compound exhibits potent antitumor activity and slowly converts to cytarabine in the liver, releasing cytarabine into the bloodstream over a prolonged period. Cytarabine ocfosfate is effective by both parenteral and oral administration and, therefore, has an advantage over the parenteral form of cytarabine or its analogs. It should be noted that cytarabine ocfosfate has major side effects such as myelosuppression and gastrointestinal toxicity.

• Originator

  Yamasa (Japan)

• 상표명

  Starasid

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