(R)-3-Benzyloxy-Pyrrolidine Hydrochloride

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H332：흡입하면 유해함

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

(R)-3-Benzyloxy-Pyrrolidine Hydrochloride 화학적 특성, 용도, 생산

• Synthesis

  After N-tert-butoxycarbonyl-(R)-3-benzyloxypyrrolidine separately obtained was dissolved in isopropanol and heated to 40 °C, isopropanol solution of hydrogen chloride was dropped for 6 hours. After the reaction finished, the mixture was cooled to 23 °C and was concentrated to distil the solvent away. Further, ethyl acetate was added and the mixture was concentrated, thereby obtaining a concentrate in an amount of about. Then, the concentrate was heated to 40 °C, and isopropanol was added until (R)-3-benzyloxypyrrolidine hydrochloride which had been separated as an oily substance became completely dissolved. After (R) -3-benzyloxypyrrolidine hydrochloride was crystallized by gradually cooling the solution and suitably adding a seed crystal, hexane was further added. At the time, crystallization solvent was in a following proportion: isopropanol/ethyl acetate/hexane = 1/71.5/71.5. A deposited crystal was subjected to filtration under reduced pressure, and the resultant wet crystal was washed with ethyl acetate, and then a wet crystal was dried under reduced pressure, thereby obtaining dry crystal of (R)-3-benzyloxypyrrolidine hydrochloride (yield of 82 %, purity of 99.8 %).
  

(R)-3-Benzyloxy-Pyrrolidine Hydrochloride 공급 업체

Global(47)Suppliers