에티아지드

에티아지드 화학적 특성, 용도, 생산

• Originator

  Ethiazide,Tokyo Tanabe,Japan,1970

• Manufacturing Process

  A mixture of 2.9 grams of 5-chloro-2,4-disulfamyl-aniline in 20 ml of anhydrous diethylene glycoldimethylether, 0.44 gram of propionaldehyde and 0.5 ml of a solution of hydrogen chloride in ethyl acetate (109.5 grams hydrogen chloride per 1,000 ml) is heated to 80° to 90°C and maintained at that temperature for 1 hour. The reaction mixture is concentrated under reduced pressure; on addition of water, the product separates and is then recrystallized from ethanol or aqueous ethanol to yield the desired 6-chloro-3- ethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide, MP 269° to 270°C.

• Therapeutic Function

  Diuretic, Cardiotonic, Smooth muscle relaxant, Respiratory stimulant

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