Perchlorate has been known to inhibit the transport of iodide into the thyroid gland, and it has been clinically used for the treatment of thyrotoxicosis since the 1950s. Industrially, perchlorate has been produced in large amounts for rocket fuels and military applications.It was discovered in the 1990s that perchlorate remains unreacted in environments such as soil, plants, and animals located in or near many military installations and rocket manufacturing facilities, at potentially thyroiddisrupting levels.