글라이코퓨롤

한글명:글라이코퓨롤

카스 번호31692-85-0

상품명:GLYCOFUROL

CBNumberCB7756948

분자식C11H21O5R

포뮬러 무게233.28

MOL 파일31692-85-0.mol

동의어(한글)

글라이코퓨롤

화학적 성질

끓는 점	100-145 °C0.4 mm Hg
밀도	1.09 g/mL at 25 °C(lit.)
증기압	4.97-37.4Pa at 20-50℃
굴절률	n20/D 1.462(lit.)
인화점	>230 °F
저장 조건	Store below +30°C.
용해도	클로로포름(소량으로 용해), 메탄올(약간 용해됨, 초음파 처리)
물리적 상태	기름
색상	무색
안정성	안정적인. 타기 쉬운. 강한 산화제와 호환되지 않습니다.
LogP	-1.21--0.38

위험 및 안전 성명

WGK 독일	3
RTECS 번호	MD0907500
HS 번호	3907 20 20

그림문자(GHS)

글라이코퓨롤 화학적 특성, 용도, 생산

화학적 성질
Glycofurol is a clear, colorless, almost odorless liquid, with a bitter taste; it produces a warm sensation on the tongue.
용도
Glycofurol is used as a carrier device for drug delivery.
생산 방법
Glycofurol is prepared by the reaction of tetrahydrofurfuryl alcohol with ethylene oxide (followed by a special purification process in the case of Glycofurol 75).
Pharmaceutical Applications
Glycofurol is used as a solvent in parenteral products for intravenous or intramuscular injection in concentrations up to 50% v/v. It has also been investigated, mainly in animal studies, for use as a penetration enhancer and solvent in topical and intranasal formulations. Glycofurol has also been used at 20% v/v concentration in a rectal formulation.
Safety
Glycofurol is mainly used as a solvent in parenteral pharmaceutical formulations and is generally regarded as a relatively nontoxic and nonirritant material at the levels used as a pharmaceutical excipient. Glycofurol can be irritant when used undiluted; its tolerability is approximately the same as propylene glycol.
Glycofurol may have an effect on liver function and may have a low potential for interaction with hepatoxins or those materials undergong extensive hepatic metabolism.
LD50 (mouse, IV): 3.5 mL/kg
저장
Stable if stored under nitrogen in a well-closed container protected from light, in a cool, dry place.
비 호환성
Incompatible with oxidizing agents.
Regulatory Status
Included in parenteral medicines licensed in Europe.

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