ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR

ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR 화학적 특성, 용도, 생산

• 용도

  Monoclonal Anti-Epidermal Growth Factor Receptor antibody produced in mouse has been used in:
  
  • western blotting
  • immunoprecipitation
  • immunocytochemistry
  • immunohistochemical staining
  
  

• 일반 설명

  Monoclonal Anti-EGFR (mouse IgG1 isotype) is derived from the hybridoma 225 produced by the fusion of mouse myeloma cells (NS-1-503 cells) and splenocytes from BALB/c mice immunized with partially purified EGF receptors from A-431 cells. The receptor for epidermal growth factor (EGF) is an integral cell membrane glycoprotein of 170 kDa, which spans the membranes of a wide range of normal and malignant epithelial cells. The EGF receptor has an intracellular domain that exhibits tyrosine kinase activity.

• Biochem/physiol Actions

  EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer.

ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR 공급 업체

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