포르모테롤

한글명:포르모테롤

카스 번호73573-87-2

상품명:Formoterol

CBNumberCB7722411

분자식C19H24N2O4

포뮬러 무게344.4

MOL 파일73573-87-2.mol

동의어(한글)

포르모테롤

포모테롤

화학적 성질

끓는 점	603.2±55.0 °C(Predicted)
밀도	1.233±0.06 g/cm3(Predicted)
용해도	DMSO: 20mg/mL, 가용성
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	8.95±0.50(Predicted)
색상	회백색
안정성	안정적인. 강한 산화제와 호환되지 않습니다.
CAS 데이터베이스	73573-87-2(CAS DataBase Reference)

위험 및 안전 성명

WGK 독일	3
유해 물질 데이터	73573-87-2(Hazardous Substances Data)

그림문자(GHS)

포르모테롤 화학적 특성, 용도, 생산

화학적 성질
solid
용도
Labeled Formoterol, intended for use as an internal standard for the quantification of Formoterol by GC- or LC-mass spectrometry.
정의
ChEBI: A phenylethanoloamine having 4-hydroxy and 3-formamido substituents on the phenyl ring and an N-(4-methoxyphenyl)propan-2-yl substituent.
일반 설명
Formoterol (Foradil) isalso a lipophilic (log P= 1.6) and long-acting β2-agonist. Ithas 3'-formylamino ( β-directing) and 4 OH groups on onephenyl ring and a lipophilic -directing N-isopropyl-pmethoxyphenylgroup on the nitrogen atom. Its long DOA(12 hours), which is comparable to that of salmeterol, hasbeen suggested to result from its association with the membranelipid bilayer, from which it gradually diffuses to provideprolonged stimulation of β2 receptors and its resistanceto MAO and COMT. Formoterol has a much faster onset ofaction than does salmeterol as result of its lower lipophilicity.Both of these long-acting drugs are used by inhalationand are recommended for maintenance treatment of asthma,usually in conjunction with an inhaled corticosteroid.
Mechanism of action
Formoterol has 3′-formylamino and 4′-hydroxy ring R3 substitution pattern but also an alkoxyphenylethyl lipophilic group R1 on the nitrogen, similar to ritodrine. Although it is less lipophilic (log P = 1.6) than salmeterol, it has a 12-hour duration of action similar to that for salmeterol. It is administered as an inhaled dry powder, because it is unstable to heat and moisture. It is a mixture of (R,R)-(–)- and (S,S)-(+)-stereoisomers, with the (R,R)-isomer having approximately 1,000-fold more affinity for the β2-receptor than the (S,S)-isomer. Because of its high potency and low dose, however, there is no clinical advantage for using (R,R)-formoterol as bronchodilator compared to the racemate. Unlike salmeterol, formoterol has a faster onset of action as a result of its lower lipophilicity. It is also more potent; a 12-μg dose of formoterol has been demonstrated to be equivalent to a 50-μg dose of salmeterol.

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