포르투넬린

포르투넬린 화학적 특성, 용도, 생산

• 개요

  Fortunellin is a potential anti-inflammation agent in inflammatory diseases, it targets miR-374a, which is a negative regulator of phosphatase and tensin homolog (PTEN). Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation.

• 화학적 성질

  Off-white to light yellow Solid

• 용도

  Fortunellin is a flavonoid that can be isolated from kumquat (Fortunella margarita) fruit. Studies have shown that Fortunellin inhibits LPS-induced inflammation and ROS production in H9C2 cells, and also prevents fructose-induced inflammation and oxidative stress by enhancing the AMPK/Nrf2 pathway. In addition, Fortunellin has a dual role in the prevention and treatment of coronaviral disease, with antiviral activity against SARS-CoV-2 and anti-inflammatory immunomodulatory capacity in the host.

• Biological Functions

  Fortunellin (acacetin 7-O-neohesperidoside) is a citrus flavonoid isolated from kumquat fruit. Kumquat extract has attracted much attention recently for its beneficial effects on human health, which include antitumor, antioxidant and anti-inflammatory characteristics . The beneficial effects of flavonoids on IBD have been confirmed in many studies. However, although fortunellin is the main flavonoid in kumquat, there is a lack of information on its alleviation of IBD.

• Mechanism of action

  Fortunellin is a citrus flavonoid that is a potential anti-inflammation agent in inflammatory diseases. Fortunellin ameliorated colitis symptoms, including excessive inflammation and oxidative stress. Fortunellin decreased epithelial cell apoptosis through inhibiting PTEN expression in colitis. Fortunellin-induced downregulation of PTEN could be counteracted by miR-374a depletion. Moreover, knockdown of miR-374a in vivo partly inhibited the effects of fortunellin on rat colitis.

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