CHROMANOL 293B

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

  H312：피부와 접촉하면 유해함

  H332：흡입하면 유해함

• 예방조치문구

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

CHROMANOL 293B 화학적 특성, 용도, 생산

• 개요

  Chromanol 293B is a blocker of slowly activating delayed-rectifier K⁺ current (I_Ks) with an IC₅₀ value of 6.89 μM in Xenopus oocytes expressing rat I_Ks channels. It is selective, having no activity at rat K_v1.1 or K_ir2.1 channels at a concentration of 30 μM. Chromanol 293B increases the rate and extent of I_Ks in guinea pig ventricular cells in a dose-dependent manner. It also inhibits cystic fibrosis transmembrane conductance regulator (CTFR) Cl^- currents (I_CTFR) with an IC₅₀ value of 19 μM in Xenopus oocytes expressing human CTFR.

• 용도

  Chromanol 293B has been used in the inhibition of calcium and cyclic adenosine monophosphate (cAMP)-activated potassium channels in human epithelial cell lines. Chromanol 293B has been used in patch-clamp electrophysiology studies in cardiomyocytes.

• 일반 설명

  Chromanol 293B enantiomer is a potent inhibitor of potassium channel protein (KvLQT1). In human atrial myocytes, chromanol 293B inhibits repolarization potassium currents. Chromanol 293B improves glucose-stimulated insulin secretion (GSIS) in pancreas by modulating potassium voltage-gated channel (KCNQ1).

• 생물학적 활성

  Blocker of the slow delayed rectifier K + current (I Ks ) (IC 50 = 1-10 μ M). Also blocks the CFTR chloride current (I CFTR ) (IC 50 = 19 μ M).

CHROMANOL 293B 공급 업체

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