4-아세틸-피페리딘-1-카르복실산TERT-부틸에스테르

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H301：삼키면 유독함

• 예방조치문구

  P301+P310：삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.

4-아세틸-피페리딘-1-카르복실산TERT-부틸에스테르 화학적 특성, 용도, 생산

• 용도

  tert-Butyl 4-Acetylpiperidine-1-carboxylate is a useful research chemical.

• Synthesis

  Tert-butyl-4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (2.29 g, 8.32 mmol) was dissolved in 30 ml of tetrahydrofuran (THF), and the resulting solution was cooled to -78 °C. To the solution, methylmagnesium bromide (3.0 M) (7.73 ml, 10.82 mmol) was slowly added, and the solution was stirred at 0 °C for 1 hr. After the reaction was completed with a 2 N hydrochloric acid aqueous solution, 6 N sodium hydroxide solution was added to adjust the pH to 10. Then the solution was extracted with dichloromethane. The organic layer was treated with magnesium sulfate (MgSO4) and filtered, and the solution was concentrated. The resulting residue was isolated and purified by silica gel column chromatography (dichloromethane/methanol = 10/1) to give 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester (6.36 g, 94.0 percent).

4-아세틸-피페리딘-1-카르복실산TERT-부틸에스테르 준비 용품 및 원자재

4-아세틸-피페리딘-1-카르복실산TERT-부틸에스테르 공급 업체

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