Thymopentin

한글명:Thymopentin

카스 번호69558-55-0

상품명:Thymopentin

CBNumberCB7491069

분자식C30H49N9O9

포뮬러 무게679.77

MOL 파일69558-55-0.mol

화학적 성질

밀도	1.44±0.1 g/cm3(Predicted)
저장 조건	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
용해도	DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
물리적 상태	가루
산도 계수 (pKa)	3.07±0.10(Predicted)
색상	하얀색
CAS 데이터베이스	69558-55-0(CAS DataBase Reference)

위험 및 안전 성명

WGK 독일

HS 번호

3504009000

NFPA 704:

	0
2		0

그림문자(GHS)

Thymopentin 화학적 특성, 용도, 생산

개요
Thymopentin is a kind of peptide. Peptides and polypeptides play a critical role in the immune system and are therefore predestined as a source for new approaches in immunotherapy. Thymopentin is capable of modulating the immune response. It is a fragment of the thymopoietins (TMPOs) which is a family of nuclear protein. Studies have shown that Thymopentin is capable of affecting the function of T cells and monocytes monitored by increased cGMP level and the triggering of cellular signaling. It is also capable of improve an imbalanced immune system. As an immunomodulating agent, it is clinically used in the treatment of autoimmune diseases such as atopic dermatitis, chronic lymphocytic leukemia, Sezary’s syndrome, rheumatoid arthritis and decreased immune competency. Recent study has also shown that its immuno-modulating effect can also help fight against the infection of mycobacterium tuberculosis.
용도
Thymopentin Acetate (TP-5) is a synthetic immunomodulating pentapeptide.
Clinical Use
Thymopentin is a synthetic, immunomodulating pentapeptide, representing the active fragment of the thymus hormone, thymopoietin. Thymopentin induces phenotypic differentiation and maturation of T-cells. It appears of value in the treatment of primary immune deficiency, rheumatoid arthritis, atopic dermatitis, sarcoidosis and a variety of other diseases with manifestations of disturbed immune balance.
참고 문헌
Zhang, Yan, et al. "Novel thymopentin release systems prepared from bioresorbable PLA–PEG–PLA hydrogels." International journal of pharmaceutics 386.1 (2010): 15-22.
Gonser, S., E. Weber, and G. Folkers. "Peptides and polypeptides as modulators of the immune response: thymopentin—an example with unknown mode of action." Pharmaceutica Acta Helvetiae 73.6 (1999): 265-273.
Wang, Ying, et al. "Synthetic modifications of the immunomodulating peptide thymopentin to confer anti-mycobacterial activity." Biomaterials 35.9 (2014): 3102-3109.

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